Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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منابع مشابه
Determination of Valproic Acid by Hplc in Human Blood and Its Relationship to Therapeutic Drug Monitoring
A novel HPLC method for the determination of valproic acid (VPA) in human serum using nonanoic acid as internal standard (I.S.) is described in this article. The eluates were separated with a reverse phase column of the dimensions C18 250 × 4.6 mm internal diameter maintained at a temperature of 48 °C. A mobile phase consisting of acetonitrile and 29mM phosphate buffer (pH 3.5) 49: 51 v/v was u...
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BACKGROUND We developed a micellar liquid chromatographic (MLC) procedure for the determination of three extensively monitored antiepileptics in serum samples: carbamazepine, phenobarbital, and phenytoin. METHODS We determined the composition of the mobile phase after modeling the elution behavior of the antiepileptics in hybrid micellar mobile phases of sodium dodecyl sulfate (SDS) with diff...
متن کاملA Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs
Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...
متن کاملTherapeutic Drug Monitoring in Pediatric Practice: A Critical Appraisal
The criteria for drug monitoring in children are almost similar as applicable in adults, though certain factors need to be taken into consideration. The dramatic pace of change in other areas of clinical therapeutics has not reflected significantly in the specialty of pediatrics, accounting for the poor development of therapeutic drug monitoring in children. Major drug interactions in the pedia...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2018
ISSN: 1940-087X
DOI: 10.3791/58148